The Oberst Lab studies how cells die, and how dying cells impact immunity.
One of our interests is in finding ways of killing cancer cells that activate the immune system. Therapies that achieve this would eliminate tumor cells while promoting beneficial immune attack on surviving cancer cells or distant metastases.
Another focus of the lab is on understanding how viruses activate the pathways of cell death, and the consequences for the host when they do so. Our work has focused on the effect of flavivirus infection in the brain, and the consequences of activation of the necroptotic pathway in this site.
More recently we have begun to investigate the cell death responses to the novel coronavirus SARS-CoV-2 in the lung, and the contribution of programmed cell death to the pathology of COVID-19 illness.
More details of our research interests can be found on the Research page.
The Oberst Lab is currently looking for highly motivated postdoctoral fellows interested intaking on new research projects spanning cell biology, cancer immunology, and neuroimmunology.
Interested? Qualified candidates are encouraged to send a CV and cover letter to: